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Thinking outside the cleft to understand synaptic activity: Contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling
Reho, Monika Tutaj, Jennifer R
Its activity is controlled by phosphorylation/dephosphorylation, with UNC-51-like kinase 1 (ULK1)-mediated phosphorylation critical for recruiting damaged mitochondria and initiating mitophagy (Zhu et al., 2022)
IP administration creates rapid systemic spikes and clearance, triggering acute stress-response pathways
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