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35 Cigarette smoke-induced oxidative stress plays role in enhancing inflammation by regulating redox-sensitive transcription factors, such as nuclear factor kappa-B (NF-B) and activating protein 1 (AP-1), the extra-cellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK) pathways
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doi: 10.1016/j.dsx.2023.102938 6
Thus, FOXO4-DRI is able to recognise and target the problem cells without damaging the healthy ones
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