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Data availability Proteomic results and summary association data are available through a dashboard at Individual participant data from the STEP 1 and STEP 2 clinical trials can be shared in datasets in a de-identified and anonymized format

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Forward and reverse primers for insulin receptor (InsR), insulin receptor substrate 1 (IRS-1), tumor necrosis factor-alpha (TNF), nuclear factor kappa B subunit 1 (NFK), interleukin-6 (IL-6), caspase-3, Bcl-2-associated X protein (BAX), and B-cell lymphoma 2 (BCL2) were acquired from Sigma Chemical Co