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With the GLP-1 receptor there is the pathway linked to insulin control, but also a pathway that recruits the signalling molecule beta arrestin, which causes the side effects but also results in the whole receptor and drug molecule being taken inside the cell, shutting down any further activity

Week 21 onward : 15 mg once weekly (maximum dose)

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Talk to your healthcare provider about the steps youve taken, such as changes to your diet, weight loss surgery, exercise habits, or behavior, and be honest about what hasnt worked