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Axel Holst and Theodor Frlich, two Norwegian physicians studying shipboard beriberi contracted by ship's crews in the Norwegian Fishing Fleet, wanted a small test mammal to substitute for the pigeons then used in beriberi research

The stability window interacts directly with the dosing schedule, and this is a practical planning point rather than a theoretical one: at 2.4 mg/week a 10 mg vial covers four weeks, which lands exactly at the outer edge of the in-use window

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It has been established that the speed of replication fork progression is regulated by TIPIN/TIMELESS complex with oligomer form of peroxiredoxin 2 (PRDX2), as a ROS sensor, in replisome