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nevertheless, the criteria for participant selection were in accordance with the FDA and EMA guidelines for DDI clinical trials [39, 40] and the use of healthy subjects prevents the potential confounding effect of concomitant medications and co-morbidities

However, these medications also face several challenges, including low stability in the body, short half-lives, poor membrane permeability, complex manufacturing processes, and high costs

( 5.2 Bacteria Upon stimulation by various bacterial species, including S.aureus , A

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