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thus, it has a long half-life and strong biological activity.78 The average half-life of exenatide is 2.4 h, 2 to 3 times per day.78 Liraglutide Liraglutide is a medication used to treat T2DM and obesity.79,80 In the treatment of T2DM, liraglutide helps lower blood sugar levels by increasing insulin production and reducing glucose production by the liver.81 It also slows stomach emptying, which helps control appetite and reduce food intake.82,83 In addition to lowering blood sugar levels, liraglutide helps to reduce body weight by suppressing appetite and reducing energy intake,84,85 but its associated costs and need for daily injections may limit its use in individuals with obesity.86,87,88 Liraglutide was first approved by the FDA in 2010 under the brand name Victoza for the treatment of T2DM.83,89,90,91,92 Since then, it has also been approved for other indications, such as chronic weight management, under the brand name Saxenda.62 Liraglutide has an arginine at position 34 (GLP-1(7-37)) that is lysine, and its lysine at position 26 connects to a 16-carbon palmitic acid side chain linked by glutamic acid

Because GLP-1 medications slow gastric motility, they can worsen bacterial overgrowth, leading to more fermentation and significantly more gas production

What the trial did reveal about timing-adjacent factors is more useful