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Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, et al
How to Protect Milk Supply While Taking GLP-1 Medications If you and your healthcare provider decide that a GLP-1 medication is appropriate during breastfeeding, nutrition becomes especially important
Phase 2 trial data (published in New England Journal of Medicine, 2023 ): 24.2% average weight loss at 48 weeks with 12 mg dose 22.8% with 8 mg dose Placebo group lost 2.1% Most recent Phase 3 trial data (TRIUMPH-4, December 2025): 28.7% average weight loss at 68 weeks with 12 mg dose 26.4% with 9 mg dose 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% weight loss For context: These are the highest weight loss numbers reported in any clinical trial for a pharmacological obesity treatment
Presented for research literature review only Di Emidio G et al
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