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Evidence and Safety Guidance Wegovy (semaglutide 2.4 mg) is a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for weight management in adults with obesity or those who are overweight with weight-related comorbidities

Most patients tolerate GLP-1 medications well, and with appropriate management strategies, side effects can usually be minimised whilst maintaining the significant metabolic benefits these medications provide

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Patients with certain genetic profiles may experience milder nausea or faster adaptation, while others benefit from starting at lower microdose levels