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Sold as Mounjaro (for diabetes) and Zepbound (for weight management), tirzepatide has quickly become the most prescribed alternative for people who want more weight loss than semaglutide delivers
All study patients and controls were informed of the rationale and procedures of this study, and written informed consent was obtained from each participant
A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-
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