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The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot
While both interventions derive from the growth hormone molecule, their safety profiles differ substantially due to AOD-9604s selective mechanism that avoids traditional GH receptor activation
The copper component is not just structural decoration
No LD50 reached in preclinical studies
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