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Early Onset Type 2 Diabetes and Tirzepatide Efficacy and Safety: A Post Hoc Analysis of the SURPASS-1, -2, and -3 Trials

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Thus, targeting key signaling axes related to macrophage polarization such as PI3K/Akt/-catenin, along with interaction pathways with fibroblasts such as P2rx4/IL-6/Arg1, may enable synergistic intervention against this disease

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