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Shepherd et al., 2012
This study suggests that Wnt signaling is required for correct differentiation of periotic mesenchymal cells
For example, due to the downregulation of genes for purinergic receptors (e.g., P2ry12 ) and potassium leak channels (e.g., Thik-1 ) in aged mice, the ability for microglia to sense hyperactive neurons and migrate toward them in order to facilitate rapid repolarization would be reduced, impairing their beneficial modulation (Hickman et al., 2013
Dont expect weight-loss or a big energy boost from B12 unless you were deficient (Mayo Clinic)
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