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doi:10.1345/aph.1M715
Comparisons With Other Diabetes Therapies Putting GLP1s in context with other antidiabetic agents offers additional insights: Thiazolidinediones (TZDs) are associated with increased fracture risk, especially in women SGLT2 inhibitors have raised concerns in some trials, particularly canagliflozin DPP-4 inhibitors appear largely neutral regarding skeletal effects Against this backdrop, GLP1s may have a neutral or possibly safer profile, though the data are not conclusive
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It is the first once-weekly oral semaglutide based tablet and has been found to be more effective than conventional treatment options for the reduction of HbA1C and mean change of body weight in the clinical studies
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