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Unlike GLP-1 agonists, the changes are compositional rather than scale-weight driven: patients may not lose significant total body weight but will show meaningful reduction in waist circumference and visceral fat volume
Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy
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and JP23H04921 to Ya.S), AMED-CREST (grant number 24gm1410007h0004 to F.O.), the Takeda Science Foundation (to F.O.), the Naito Foundation (to F.O.), AMED-PRIME (grant number JP21gm6410012 to A.E.), the MEXT Leading Initiative for Excellent Young Researchers (to Yu.S.), Tottori University Research Support Project for the Next Generation (to Yu.S.), and the Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo (to Ya.S
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