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Increasing glutathione levels can provide significant health benefits by supporting function, reducing oxidative stress, and promoting a healthy immune response

8 The GlyNAC combination (glycine + NAC, addressing both rate-limiting precursors simultaneously) produced particularly robust results in a 16-week, placebo-controlled RCT in older adults: it corrected glutathione deficiency, reduced oxidative stress, improved mitochondrial fatty-acid oxidation, and enhanced physical performance measures including gait speed and the 6-minute walk test

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The binding site for the hydrophobic electrophiles, or H site, is located immediately adjacent to the G site and forms part of the solvent-exposed cleft between both domains