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Similar results were observed in the STEP-HFpEF DM trial

Blood 136 , 99 (2020)

(PubMed) Thal LJ, Calvani M, Amato A, Carta A

In vitro, GH-RH stimulated multiple pathways involved in inflammation and growth in both BPH-1 and PrEp cells, including NF-B p65, AKT, ERK1/2, EGFR, STAT3, and increased the levels of TGF-1 and the transactivation of the IGF receptor