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In addition, DTSS NPs are formed by co-assembling salinomycin with thymopentin (TP5) and the ER-targeting photosensitizer s-780 and modified with DSPE-PEG-biotin, and the high heat and ROS generated by s-780 further induce ER stress thereby downregulating PD-L1 expression and activating the cGAS-STING pathway, while the loaded TP5 significantly promotes the proliferation and differentiation of T cells thereby enhancing anti-tumor immunity and inhibiting cancer metastasis and recurrence (232)

Smith AD, Castro SL, Zigmond MJ

Clinical evidence and real-world data from three large cardiovascular trials (LEADER, SUSTAIN 6, and PIONEER 6) have also supported the beneficial effect of GLP-1RAs in dementia (Nrgaard et al., 2022)

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