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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

If you are currently suffering with any infections, are taking antibiotics or have current cold and flu symptoms, then having the Vitamin B12 shot at that time is contraindicated