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however, robust human clinical evidence for these effects particularly following systemic administration is lacking

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For deficiency, weekly injections are common during the loading phase, and monthly maintenance is standard long-term

After assigning the DDB1, DDA1, DET1 and COP1 (Alphafold model: AF-Q8NHY2-F1) molecules in the density map, we observed additional densities whose corresponding protein identities could not be determined (Supplementary Fig