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Key areas including the role of glucagon in the kidney, the effect of glucagon on the heart, and the question of the importance of GCGR signalling for brain-associated metabolism and function including appetite and food intake, remain unresolved

GLP-1s have moved from social media, family group chats, and dinner-table discussions to clinical conversations to employer benefits meetings, almost overnight

It remains one of the most talked-about investigational peptides because of its innovative characteristics, growing research interest, and potential value within controlled laboratory environments.

Acta Neuropsychiatr 34:318329 Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Al Batran R, Seubert JM, Lopaschuk GD (2018) Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-COA: a possible mechanism for regulation of cardiac energy metabolism