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ARA-290 received FDA Orphan Drug Designation for this indication TRPV1-mediated pain models ARA-290 demonstrated specific inhibition of TRPV1 channel activity, relieving capsaicin-induced mechanical hypersensitivity in pre-clinical nociceptor models Complex Regional Pain Syndrome (CRPS) investigational studies have examined ARA-290 in CRPS models due to its dual anti-inflammatory and nociceptor-targeting mechanism Chronic neuropathic pain multiple studies confirm ARA-290 reduces neuroinflammation in the spinal cord by suppressing TNF-, IL-1, and other pro-inflammatory cytokines that maintain chronic pain states Neuroprotection and CNS Research: Cerebral ischaemia/stroke models Wang et al
It has been reported that Ku deficiency affects NHEJ efficiency and leads to an error-prone end-joining (Mansour et al., in vitro assay show that HSV-1 infection induces an impairment in NHEJ activity, which is increased in the presence of MG132, suggesting that the proteasomal machinery is involved in this virus-driven cascade leading to DNA repair dysfunction
