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Extra weight and insulin resistance reduce GLP-1 secretion as well as beta cell (insulin-secreting cells in the pancreas) responsiveness
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In atherosclerotic disease, GLP-1RAs have been shown to attenuate and stabilize development of atherosclerotic plaques through anti-inflammatory mechanisms (inhibition of IL-6 and TNF-, and NF-B), inhibit activation and recruitment of macrophages and prevent vascular remodeling
Sexual function The IIEF-5 questionnaire, a validated questionnaire for assessing the presence and severity of ED, was administered to all patients
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