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For patients with a baseline BMI 35, discontinuation rates due to adverse events were 8.8% and 12.1% for the 9 mg and 12 mg doses, respectively, compared to 4.8% with placebo. High drop-out rate may explain the difference between the efficacy and treatment regimen estimands: 28.7% vs

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In addition, the long-term effects and side effects of GLP-1R agonists need more in-depth studies

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