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How Do the Two Mechanisms Actually Differ

Additionally, L-Carnitine: Buffers acetyl-CoA buildup during high-fat metabolism Mitigates toxic acyl-CoA accumulation in metabolic diseases Scavenges free radicals and chelates metal ions (antioxidant role) Regulates membrane fluidity and stabilizes mitochondrial membranes Modulates fatty acid oxidation enzymes via PPAR pathways Carnitine deficiency is linked to mitochondrial dysfunction, muscle weakness, and lipid accumulation

Inhaled forms may trigger asthma symptoms in patients with asthma

Together, these findings underscore that LC's variable clinical efficacy arises from interacting factors including patient phenotype, dosing strategy, intervention duration, and endpoint sensitivity