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Tofacitinib) display powerful anti-inflammatory effects and significantly decrease mitochondrial membrane potential, mitochondrial mass and ROS production in RA synovial fibroblasts (162)
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Collagen remodeling is a multi-week process governed by fibroblast gene expression, procollagen synthesis, and matrix metalloproteinase regulation
Due to abnormal intracranial PLP transport in patients with TNSALP mutations, there is insufficient neurotransmitter synthesis in the brain, which eventually contributes to PL-dependent seizures, usually preceding the onset of skeletal changes [41, 49,50,51,52]
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