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3.1.1 Indoxyl sulfate (IS) Indoxyl sulfate (IS) is classified as a protein-bound uremic toxin, with its biosynthesis originating from tryptophan metabolism: gut microbiota first convert tryptophan into indole, which is then transported to the liver for oxidation and sulfation to form IS (Meyer and Hostetter, 2012)
Gut healing and protection: The blend supports gut healing and protection, useful for research on gut health and inflammatory bowel conditions
NNMT inhibitors NNMT has garnered significant attention due to its role in various metabolic processes and its potential as a therapeutic target 195
Special thanks to Jing Zhang (Shanghai Tongren Hospital) for his contributions to the NHANES database
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