doi:10.1016/j.biopsych.2012.06.028 Serviddio G, Romano AD, Cassano T, Bellanti F, Altomare E, Vendemiale G (2011) Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases
However, stressors such as pollution and poor diet can skew this balance and contribute to oxidative stress, a key factor in various health issues
GSH the body's most abundant intracellular antioxidant (non-enzyme), plays a vital role in combating oxidative stress and is known to decrease with aging
Chromosome 21 overexpression leads to alterations in genes encoding interferon receptors, proinflammatory cytokines, and oxidative stress modulators such as SOD1 71 , creating an immunometabolic environment that is both permissive to microbial imbalance and vulnerable to its consequences