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This has historically been one of the difficulties in validating the benefits of its use
A primary concern for menopausal GLP-1 users is the potential for accelerated bone thinning and muscle loss, which is why experts emphasize the necessity of a high protein intake and consistent strength training to mitigate these risks
cardiovascular system improvements in blood pressure, non-HDL cholesterol, and inflammatory markers across SURMOUNT trials ( Tandfonline, 2024 )
Most discontinuations in both trials occurred during the first 24 weeks of dose escalation
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