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These NAD + -dependent deacetylases regulate mitochondrial biogenesis through transcriptional players such as the peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), as well as pathways involved in DNA repair and redox balance [253, 254]

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A dulled needle causes more tissue damage, more pain, and creates a larger opening in the rubber stopper that accelerates coring

Front Neural Circuits 3 , 16 (2010)