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Individuals with obesity face a markedly increased risk of comorbidities such as dyslipidaemia, T2D, hypertension, coronary heart disease, stroke, gallbladder disease, respiratory disorders, sleep apnoea, osteoarthritis, and certain types of cancer [142]
Intriguingly, recent studies have expanded the therapeutic scope of GLP-1RAs to neuroinflammatory regulation, with promising therapeutic potential observed in neurodegenerative disorders including Alzheimers disease, Parkinsons disease, and amyotrophic lateral sclerosis [271, 272]
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Head-to-head evidence suggests tirzepatide may produce greater average weight loss in eligible trial populations
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