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EVIDENCE GRADES 12-week Metabolic Pharmaceuticals Phase 2b at 1 mg/day did not meet primary weight-loss endpoint
avoid repeated freezethaw cycles.
Presented for research literature review only Kruse T et al
In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis
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