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Bioeng Transl Med 1(1):1029 Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia inducible factor

Once the decision to initiate pharmacotherapy is made, metformin is recommended as the initial antihyperglycemic medication because of its durable efficacy in lowering A1C, negligible risk for hypoglycemia or weight gain [12] [Grade A, Level 1A], relatively mild side-effect profile, long-term track record, and affordability

Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971