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To meet the diagnostic criteria for cEDS, a person must meet: Major criterion 1 AND major criterion 2 OR Major criterion 1 AND three or more minor criteria Major Criteria Skin hyperextensibility and atrophic scarring Generalized joint hypermobility Minor Criteria Easy bruising Soft, doughy skin Skin fragility (or traumatic splitting) Molluscoid pseudotumors Subcutaneous spheroids Hernia (or history thereof) Epicanthal folds Complications of joint hypermobility (e.g., sprains, dislocations/subluxations, pain, flexible flatfoot) Family history of a first-degree relative who meets clinical criteria Genetic testing is used to see if a person has a genetic variant that causes vEDS
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Analytical Specifications Product type: Research peptide blend Appearance: White to off-white lyophilized solid Purity: At least 99%
1 The Components of Each CYANOKIT Each CYANOKIT consists of 1 : Dosing and Administration for CYANOKIT Recommended Dosing for CYANOKIT 1 The starting dose of CYANOKIT for adults is 5 g (contained in a single vial), administered by IV infusion over 15 minutes (approximately 15 mL/min)* Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by IV infusion up to a total dose of 10 g The rate of infusion for a potential second dose may range from 15 minutes (for patients in extremis) to 2 hours, as clinically indicated *No safety and efficacy studies have been performed in pediatric patients
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