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GaoJFanHWangXChengYHaoJHanSet al

While selectivity over classical ERs is reported at relevant concentrations, nuclear-receptor cross-reactivity and downstream network effects remain theoretical risks in longer or higher-exposure studies

To address this question, we mutated Tyr110 in the CPYS-motif of ScGrx7 as a candidate residue that might contribute to the glutathione activator site (see Discussion for details) and performed a preliminary study with wild-type ScGrx7 as a control