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Supplementing diets with extra cysteine and glycine may be a secure, affordable, and creative way to boost GSH production and concentrations which can neutralise the ROS produced during anaerobic glycolysis, Schiff reaction, glycation, glucose autoxidation, and metabolism of hexosamine under supraphysiological glucose concentrations

Glutathione when administered IV works immediately because it bypasses the rate-limiting step of glutathione synthesis

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[3] [4] In plants, the glutathione-ascorbate cycle operates in the cytosol, mitochondria, plastids and peroxisomes