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Similarly, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, GLP-1 analogues were reported to protect the brain from MPTP-induced pathological effects, such as movement disorders, increased levels of -synuclein, chronic inflammation in the brain, loss of dopaminergic neurons, oxidative stress, and expression of growth factors (65)

1 Notably, OPLL manifests with heightened clinical severity due to the ligaments unique anatomical positioning directly anterior to the spinal cord within the vertebral canal

Their duration appears to be brief

In addition, GLP-1 receptor activation appears to enhance endothelial function and reduce oxidative stress