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In this scenario, a 22% reduction in the extraction ratio has resulted in a 200% (three-fold) increase in the amount of drug reaching the systemic circulation

The latest dual-action GLP-1 analogue, tirzepatide , which also affects GIP receptors, was approved in the US in 2022 as the drug Mounjaro for the treatment of type 2 diabetes, and in 2023 as Zepbound for the treatment of obesity and excess weight, as well as obstructive sleep apnea syndrome in obese individuals

Protein expression of eIF4F complex proteins EIF4A1, EIF4E, and EIF4G1 (n = 162 patients)