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Recent work has highlighted an auxiliary Fe-S binding protein which may buffer complex I Fe-S cluster levels- the CDGSH iron-sulfur domain 3 protein (CISD3 or MiNT)
Side Effects: Sedation Fatigue Depression (suicidal tendencies) Parkinsonism symptoms Hypotension Bradycardia Chest pain Gastric ulceration Diarrhea & vomiting Dry mouth Syncope & arrhythmias For more see Cheung & Parmar (2022) Pharmacokinetics: Reserpine readily crosses the blood brain barrier & depletes cerebral catecholamine stores
299 Elevated serum uric acid levels constitute a substantial risk factor for both the onset and progression of hypertension
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