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Topical effects Most reported topical effects are mild and local: redness, tingling, dryness, or transient irritation at the application site, typically more common with concentrations above 4%
Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class
Moiz A, Filion KB, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ
Read More Find out more about when surgery for a carotid artery blockage is recommended by Dr
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