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01Mechanism of action ERR receptors Orphan nuclear receptor family Estrogen-Related Receptors (ERRalpha, beta, gamma) were isolated in 1988 by Vincent Giguere (Nature 331:91) based on strong sequence homology with the estrogen receptor alpha (ESR1) in their DNA-binding (DBD, 68% identity) and ligand-binding (LBD, 36% identity) domains
Timing is mechanism-dependent
Gao Y, Baharudin F, Zhang Y, Tan K, Zhang Y, Li M, et al
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Furthermore, L-carnitine works synergistically with endothelial pathways to improve nitric oxide production, supporting healthy blood vessel constriction and dilation
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