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Using a nanoluciferase tag at the GLP-1R C-terminus, we were also able to obtain BRET measurements of GLP-1R redistribution to early, late and recycling endosomes that corroborate the TR-FRET responses
Winter L, Pawlowsky L, Marcinek A, Brauchle B, Muth A, Kazerani M, Petrera A, Kischel R, Emhardt AJ, Rothenberg-Thurley M, Dufour AM, Spiekermann K, Andreeff M , Daver N, Buecklein VL, and Subklewe M
Expert Commentary The rise of GLP-1 receptor agonists like semaglutide and tirzepatide reflects a major shift in how we approach both type 2 diabetes and obesity
Novo Nordisk originally developed the active ingredient to treat type 2 diabetes
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