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This approach may help overcome drug resistance by simultaneously targeting multiple cellular pathways

There is a higher prevalence of type 2 diabetes mellitus (DT2) in patients with PsO than in the general population.25 In addition, insulin resistance induces dyslipidemia and contributes to the development of nonalcoholic hepatic steatosis (NAHS).26 Cardiovascular risk (CVR) is increased in patients with obesity and PsO who present psoriatic arthritis, and who often have other risk factors.27 The guidelines for the European Cardiology Society state that the body mass index (BMI) should not exceed 25kg/m2,28 and so early interventions to manage obesity or excess weight associated with PsO could contribute to preventing CVR

In fibroblast cultures, GHK-Cu stimulates the synthesis of extracellular matrix proteins collagen, elastin and glycosaminoglycans (Maquart et al

Consider HRT where appropriate Hormone Replacement Therapy is not licensed as a weight management treatment, but by replacing some of the oestrogen that has declined, it can support insulin sensitivity, reduce inflammation, and improve sleep, mood and energy in ways that indirectly help with weight