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Start with protein-rich meals, add fiber-containing foods you tolerate, include fluids, and choose smaller meals if large portions cause nausea or fullness

Phentermine is also a reasonable first-line option for younger patients without cardiovascular risk factors who want to try medication-assisted weight loss without committing to a more intensive and expensive regimen

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C1-31 and C4-10 bind solely through hydrophobic interactions, whereas C1-27 binding incorporates both hydrophobic and hydrophilic interactions