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Metformin) with diagnosis of type 2 diabetes Documented history of lifestyle intervention Quarterly clinical review to assess improvement (weight loss or A1C) Discontinuation if there is no measurable improvement after 6 months 3
Despite major technological advances, the pharmaceutical industry has experienced a consistent decline in R&D efficiency over the past six decades, with the number of new drugs approved per billion US dollars spent halving approximately every nine years, a trend referred to as Erooms Law (Moores Law backwards) 1
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