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Since egr-1 is critical in proliferation, differentiation, and inflammation during cholestatic liver injury, cytokine and growth factor generation and early extracellular matrix (collagen) formation (Kim et al., 2006
A recent study of Parkin-deficient human dopaminergic neurons demonstrated that while there was defective mitophagy in human dopaminergic neurons lacking Parkin, the mitochondrial dysfunction is chiefly a consequence of defects in mitochondrial biogenesis (Kumar et al., 2020)
Higuchi T, Abe M, Yamazaki T, Mizuno M, Okawa E, Ando H
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