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Dysesthesia: A New Signal for Retatrutide The TRIUMPH-4 Phase 3 trial revealed an unexpected finding: dysesthesia (abnormal touch sensations where normal sensations feel unusual or painful) in 20.9% of participants on 12 mg and 8.8% on 9 mg, compared to 0.7% on placebo (BioSpace, Dec 2025)

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161 In another trial, 30 healthy university students reported shorter time to sleep onset and better overall sleep quality after having a hop-containing non-alcoholic beer with dinner nightly for two weeks compared with the week before they had the beer