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This dual activation produces stronger appetite suppression, greater weight loss, and improved metabolic markers compared to GLP-1-only medications in head-to-head clinical trials

Retrieved from Pitt, R.D., Pilz, J., et al

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Similar increases in mitochondrial proteins involved in oxidative phosphorylation were observed in a placebo-controlled trial of pioglitazone 15 mg once daily given for 6 months [125]