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Mounjaro for diabetes) demonstrated significant weight loss in the SURMOUNT-1 trial published in the New England Journal of Medicine (2022), with mean reductions of 1522% depending on dose
Calling them interchangeable because they share a primary target is like saying a scalpel and surgical scissors are the same tool because they both cut
Retention of these higher levels of C-peptide do not preclude PDM when Tier 1 criteria are satisfied, but rather suggest the presence of a transitional stage in the natural history of pancreatogenic diabetes, identifying an at-risk population for future insulin deficiency, glycaemic instability, and exocrine failure meriting more intensive oversight and individualized intervention
Weight loss continues progressively throughout the first year of treatment, with peak effects typically observed around 72 weeks
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