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Once in circulation, GLP-1 is rapidly degraded by DPP-4, which cleaves the active hormone to form GLP-1(9-36) with significantly reduced insulinotropic activity
Phase I dose escalation study of the oral multi-kinase VEGF inhibitor regorafenib and the anti-EGFR monoclonal antibody cetuximab in patients with advanced solid tumors including colorectal cancer
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